Chemistry of maduramicin. II. Decarboxylation, abnormal ketalization and dehydration.
نویسندگان
چکیده
The behavior of the free acid and ammonium salt of maduramicin towards heat and alcohols is examined. In refluxing lower alcohols the free acid material is decarboxylated. In addition a bisketal decarboxylated compound as well as an A-ring monoketal decarboxylated derivative are formed. Heating the ammonium salt of the ionophores in suspension in water, or dissolved in inert solvents such as heptane or xylene can cause decarboxylation as well as concomitant dehydration of the F-ring. Reaction of dansyl chloride with the free acid of maduramicin can cause dehydration of the B-ring under very mild conditions.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 39 11 شماره
صفحات -
تاریخ انتشار 1986